全文获取类型
收费全文 | 34020篇 |
免费 | 3664篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 205篇 |
儿科学 | 1093篇 |
妇产科学 | 964篇 |
基础医学 | 4813篇 |
口腔科学 | 697篇 |
临床医学 | 4100篇 |
内科学 | 6074篇 |
皮肤病学 | 546篇 |
神经病学 | 2992篇 |
特种医学 | 1401篇 |
外国民族医学 | 3篇 |
外科学 | 4381篇 |
综合类 | 752篇 |
一般理论 | 43篇 |
预防医学 | 4164篇 |
眼科学 | 878篇 |
药学 | 2573篇 |
中国医学 | 44篇 |
肿瘤学 | 1982篇 |
出版年
2021年 | 557篇 |
2020年 | 327篇 |
2019年 | 573篇 |
2018年 | 598篇 |
2017年 | 462篇 |
2016年 | 511篇 |
2015年 | 543篇 |
2014年 | 758篇 |
2013年 | 1134篇 |
2012年 | 1632篇 |
2011年 | 1595篇 |
2010年 | 933篇 |
2009年 | 835篇 |
2008年 | 1450篇 |
2007年 | 1531篇 |
2006年 | 1530篇 |
2005年 | 1464篇 |
2004年 | 1430篇 |
2003年 | 1339篇 |
2002年 | 1268篇 |
2001年 | 1185篇 |
2000年 | 1194篇 |
1999年 | 1023篇 |
1998年 | 389篇 |
1997年 | 352篇 |
1996年 | 320篇 |
1995年 | 292篇 |
1994年 | 326篇 |
1993年 | 317篇 |
1992年 | 813篇 |
1991年 | 779篇 |
1990年 | 767篇 |
1989年 | 666篇 |
1988年 | 689篇 |
1987年 | 642篇 |
1986年 | 594篇 |
1985年 | 656篇 |
1984年 | 531篇 |
1983年 | 415篇 |
1982年 | 263篇 |
1981年 | 274篇 |
1980年 | 250篇 |
1979年 | 460篇 |
1978年 | 340篇 |
1977年 | 255篇 |
1976年 | 269篇 |
1975年 | 251篇 |
1974年 | 285篇 |
1973年 | 261篇 |
1972年 | 268篇 |
排序方式: 共有10000条查询结果,搜索用时 234 毫秒
71.
72.
73.
Rachel Tham Shyamali C. Dharmage Philip E. Taylor Constance H. Katelaris Don Vicendese Michael J. Abramson Bircan Erbas 《Pediatric allergy and immunology》2014,25(5):439-449
Asthma is a significant global public health issue. Severe asthma exacerbations can be triggered by environmental factors and require medical care from health services. Although it is known that fungal exposure may lead to allergic sensitization, little is understood about its impact on asthma exacerbations. This review aims to examine whether outdoor fungi play a significant role in child asthma exacerbations. Systematic search of seven electronic databases and hand searching for peer‐reviewed studies published in English, up to 31 August 2013. Inclusion criteria were study population aged <18 yr, diagnosis of asthma, attended a health service; outdoor fungi exposure was reported. Quality and risk of bias assessments were conducted. Due to significant heterogeneity, meta‐analysis was not conducted. Of the 1896 articles found, 15 were eligible. Findings were not consistent, possibly due to methodological variations in exposure classifications, statistical methods and inclusion of confounders. Cross‐sectional studies found no or weak associations. All but one time series studies indicated an association that varied between fungal species. Increasing evidence indicates that asthmatic children are susceptible to asthma exacerbations when exposed to outdoor fungal spores. There is limited understanding of the contributions of different fungal species. Research is needed to investigate interactions of outdoor fungi with pollen, air pollutants and respiratory viruses. 相似文献
74.
Amie J. Dirks‐Naylor Samir A. Kouzi Joseph D. Bero Diep T. Phan Heather N. Taylor Stephanie D. Whitt Raean Mabolo 《Fundamental & clinical pharmacology》2014,28(6):633-642
Doxorubicin (Dox) is an effective chemotherapeutic agent, but known to cause cardiac and hepatic toxicity. Mechanisms of toxicity have not been clearly identified, but shown to involve oxidative stress and mitochondrial dysfunction. However, antioxidant supplementation has only shown modest protection from Dox‐induced toxicity in clinical trials. Therefore, further research is required to discern alternative mechanisms that may also play an important role in Dox‐induced toxicity. Thus, we aimed to investigate the role of mitochondrial fusion and fission in Dox‐induced hepatic toxicity, which has not yet been investigated. Six‐week‐old male F344 rats were injected IP with 20 mg/kg of Dox or saline. Once administered, both groups of animals were fasted with no food or water until sacrifice 24 h later. Dox decreased content of primary regulators of mitochondrial fusion (OPA1, MFN1, and MFN2) with no effect on regulators of fission (DRP1 and FIS1), thus shifting the balance favoring mitochondrial fission. Moreover, it was determined that mitochondrial fission was likely not coupled to cell proliferation or cytochrome c release leading to the activation of mitochondrial‐mediated apoptotic signaling. Rather, mitochondrial fission may be coupled to mitophagy and may be an adaptive response to protect against Dox‐induced hepatic toxicity. This is the first study to report the role of altered mitochondrial dynamics and mitophagy machinery in Dox‐induced hepatic injury. 相似文献
75.
D. E. Stewart S. M. Tlusty K. H. Taylor R. S. Brown H. N. Neil D. K. Klassen J. A. Davis T. M. Daly P. C. Camp A. M. Doyle 《American journal of transplantation》2015,15(12):3123-3133
Analysis and dissemination of transplant patient safety data are essential to understanding key issues facing the transplant community and fostering a “culture of safety.” The Organ Procurement and Transplantation Network's (OPTN) Operations and Safety Committee de‐identified safety situations reported through several mechanisms, including the OPTN's online patient safety portal, through which the number of reported cases has risen sharply. From 2012 to 2013, 438 events were received through either the online portal or other reporting pathways, and about half were self‐reports. Communication breakdowns (22.8%) and testing issues (16.0%) were the most common types. Events included preventable errors that led to organ discard as well as near misses. Among events reported by Organ Procurement Organization (OPOs), half came from just 10 of the 58 institutions, while half of events reported by transplant centers came from just 21 of 250 institutions. Thirteen (23%) OPOs and 155 (62%) transplant centers reported no events, suggesting substantial underreporting of safety‐related errors to the national database. This is the first comprehensive, published report of the OPTN's safety efforts. Our goals are to raise awareness of safety data recently reported to the OPTN, encourage additional reporting, and spur systems improvements to mitigate future risk. 相似文献
76.
77.
High‐Resolution HLA Typing for Sensitized Patients: Advances in Medicine and Science Require Us to Challenge Existing Paradigms 下载免费PDF全文
R. J. Duquesnoy H. M. Gebel E. S. Woodle P. Nickerson L. A. Baxter‐Lowe R. A. Bray F. H. J. Claas D. D. Eckels J. J. Friedewald S. V. Fuggle J. A. Gerlach J. J. Fung M. Kamoun D. Middleton R. Shapiro A. R. Tambur C. J. Taylor K. Tinckam A. Zeevi 《American journal of transplantation》2015,15(10):2780-2781
78.
Establishment of primary patient‐derived xenografts of palliative TURP specimens to study castrate‐resistant prostate cancer 下载免费PDF全文
79.
Transcriptional Profiling of Laser Capture Microdissected Subpopulations of the Osteoblast Lineage Provides Insight Into the Early Response to Sclerostin Antibody in Rats 下载免费PDF全文
80.